Found 5 hits of ki for drug = Aptensio Xr Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50062915
(CHEMBL827 | METHYLPHENIDATE | methyl (2R)-phenyl[(...)Show InChI InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13-/m1/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
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CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]WIN-35,428 from human DAT expressed in mouse N2A cells after 15 mins by liquid scintillation counting |
ACS Med Chem Lett 3: 378-382 (2012)
Article DOI: 10.1021/ml3000098 BindingDB Entry DOI: 10.7270/Q2FX7BHG |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50062915
(CHEMBL827 | METHYLPHENIDATE | methyl (2R)-phenyl[(...)Show InChI InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13-/m1/s1 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Mylan School of Pharmacy
Curated by ChEMBL
| Assay Description Displacement of [3H]WIN-35428 from human DAT stably expressed in mouse N2A cells by scintillation countnig |
Bioorg Med Chem 19: 504-12 (2011)
Article DOI: 10.1016/j.bmc.2010.11.002 BindingDB Entry DOI: 10.7270/Q29Z9567 |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50062915
(CHEMBL827 | METHYLPHENIDATE | methyl (2R)-phenyl[(...)Show InChI InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 125 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 301: 1097-102 (2002)
Article DOI: 10.1124/jpet.301.3.1097 BindingDB Entry DOI: 10.7270/Q2ZW1JH0 |
More data for this Ligand-Target Pair | |
Norepinephrine transporter
(RAT) | BDBM50062915
(CHEMBL827 | METHYLPHENIDATE | methyl (2R)-phenyl[(...)Show InChI InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13-/m1/s1 | UniProtKB/TrEMBL
GoogleScholar AffyNet
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CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 301: 1097-102 (2002)
Article DOI: 10.1124/jpet.301.3.1097 BindingDB Entry DOI: 10.7270/Q2ZW1JH0 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50062915
(CHEMBL827 | METHYLPHENIDATE | methyl (2R)-phenyl[(...)Show InChI InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3/t12-,13-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 301: 1097-102 (2002)
Article DOI: 10.1124/jpet.301.3.1097 BindingDB Entry DOI: 10.7270/Q2ZW1JH0 |
More data for this Ligand-Target Pair | |